Collagen vs Collagen Peptides: What’s the Difference?

Collagen and collagen peptides, while both belonging to the same protein family, exhibit distinct characteristics. Collagen is a macromolecular fibrous hard protein, whereas collagen peptides are small-molecule polypeptides formed through the enzymatic treatment of collagen. Although they share the same amino acid composition, their properties differ due to their molecular structure.


Definition and Characteristics:

Collagen stands as the most prevalent protein in mammals and serves as the primary extracellular protein in the body, constituting approximately 25% of the total protein. It is predominantly found in fibrous tissues such as skin, ligaments, and tendons.

Molecular Structure:

Collagen is a simple peptide comprising a long helical peptide chain, containing amino acids like proline, glycine, hydroxyproline, and hydroxylysine. It has a molecular weight of about 300-400kDa, rendering it insoluble and resistant to absorption or digestion.


Collagen provides strength and elasticity to tissues, working alongside soft keratin for skin resilience. Its presence varies across different tissues, with significant concentrations in the skin, cartilage, cornea, bones, blood vessels, and more.

Real Value:

Promotes wound healing.

Facilitates hemostasis.

Supplies raw materials for collagen regeneration.

Contributes to brightening skin tone and reducing spots.

Collagen Peptides:

Definition and Characteristics:

Collagen peptides, also known as hydrolyzed collagen, are short-chain bioactive peptides resulting from collagenase hydrolysis. These peptides have a molecular weight of up to 5000 Da.

Production Process:

Collagen peptides are obtained through controlled enzymatic breakdown of the bonds between individual collagen chains, leading to specific patterns of collagen fragments based on the applied enzymatic process.

Health Benefits:

Collagen peptides offer various health benefits, serving as building blocks for bones, skin, joints, and other tissues. These benefits include skin enhancement, healthy aging, bone and joint support, gut health, and applications in sports nutrition.

Difference Between Collagen and Collagen Peptides:


  • Main extracellular protein in fibrous tissues.

  • Molecular weight around 300-400kDa.

  • Insoluble in water.

  • Uses include bone transplantation, tissue regeneration, and cosmetic surgery.

  • Commonly produced by fibroblasts.

Collagen Peptides:

  • Short-chain bioactive peptides.

  • Molecular weight up to 5000 Da.

  • Soluble in cold water.

  • Benefits include skin beautification, healthy aging, and sports nutrition.

  • Produced through enzymatic breakdown.

Summary of Collagen and Collagen Peptides:

Collagen is a foundational extracellular protein in fibrous tissues, while collagen peptides are derived through enzymatic hydrolysis, offering various health benefits. Collagen’s molecular weight is higher compared to soluble collagen peptides. Collagen has applications in surgeries, while collagen peptides are easily digestible and soluble in water, making them suitable for nutritional purposes.

As a professional collagen production facility, we are committed to delivering high-quality collagen products tailored to diverse applications.